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Philadel- phia, Pa: Saunders; 1990. 1 Mouse: 14 Mouse: X-D Mouse: 14-D1 Selective an- tagonists (IC50) LY-255883 (10 nM) Montelukast (MK476) none CP-195543 (570 nM) ICI198615 U-75302 (1 μM) Pobilukast (SFK104353) CP-105696 (58 nM) Zafirlukast (ICI204219) ZK-158252 (260 nM) Pranlukast (ONO1078) Expression (Human) Tissues: Leukocytes, thymus, spleen, liver, ovary Cells: PBLs, neutrophils,T-cells, dendritic cells, mast cells, eo- sinophils, macrophages, leu- kocytes Tissues: spleen, small intestine, placenta, lung smooth muscle, Cells: bronchial smooth muscle, CD34 hemapoietic progenitor cells, monocytes, macrophages, mast cells, eosinophils, neutro- phils, PBLs, human umbilical vein endothelial cells Tissues: heart, skeletal muscle, spleen, brain, lymp node, adrenal medulla, lung, human pumonary saphenous vein Cells: monocytes, macrophages, mast cells, eosino- phils, cardiac muscle, coronary artery, PBLs Expression (Mouse) Tissues: lungs, Cells: myeloid leukocytes, neutrophils, T- cells, macrophages, mast cells, eosinophils Tissues: lung, skin, small intestine Cells: macrophages, fibroblasts, leukocytes Tissues: lung, skin, brain, small intestine, spleen Cells: macro- phages, fibroblasts, endothelial cells, leukocytes aPartial agonist in some tissues.
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