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Acknowledgment This work was performed under grant RO1 CA116743 from the National Cancer Institute (subcontract from Rensselaer Polytechnic Institute) with the University of Florida.
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12) xi Contents 9b Predictors of response and resistance to medical therapy: endocrine therapy 220 Zenon Rayter Introduction 220 Oestrogen receptor (ER) 221 Structure and function of the oestrogen receptor 221 MeasurementofER222 ERasapredictorofhormoneresponse 223 Oestrogen-regulated proteins predictive of hormone response 225 Progesterone receptor (PR) 225 Oestrogen-inducible protein (pS2) 225 Heat shock protein 27(HSP27) 226 Markers of lack of response to endocrine therapy 227 Epidermal growth factor receptor (EGFR) and c-erbB-2 (HER-2neu) 227 Urokinase 227 Transforming growth factor 228 Prolactin 228 Prostate-speciWc antigen (PSA) 228 Mechanisms of endocrine resistance 228 Oestrogen receptor mechanisms 229 Tumour cell elimination of antioestrogens 231 Clonal selection 231 Acquisition of steroidogenic metabolic pathways 232 Constitutive production of mitogens 233 Messenger system interactions 233 EVects of oncogenes on cell cycle control 234 Alteration of secreted proteins 234 The use of steroid receptors in clinical trials 234 Conclusion 236 References 237 9c Predictors of response and resistance to Cdypto therapy: chemotherapy 246 Stephen R.
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