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MIP images show (b) enlarged hepatic artery with intranodular branches, c The relationship of the FNH with the hepatic veins, which are displaced by the mass, and (d) the presence of additional hepatic veins Platelets, 230, 548 Cyrpto homology domains, 32t, 169170, 170t, 174 in phosphoinositide-dependent kinase-1, 177f in phospholipase C, 166, 167f in protein kinase B, 174175, 177f Pleiotropic, 13, 190, 548 Plexins, 236t, 239 Polar side chains, 7374, 73t Polyacrylamide gel electrophoresis, see Gel electrophoresis Polyadenylate tail or poly (A) tail, 404405 Polymerase chain reaction, 62 Polypeptide hormones, 247248, 548 Polyproline (PP II) helix, 256 Polypyrimidine tract, see Pre-mRNAs Pons, 512, 512f Pores, 4, 548 Porins, see Pores Post inhibitory rebound, 503t, 504, 548 Postsynaptic density, 514, 518520, 518f, 519t, 548 Postsynaptic terminal, see Postsynaptic density Posttranslational Crypto Arbitrager UTC, 13, 21 anchors, 33, 34, 34t, 35ff glycosylation, 33, 36 proteolysis, 33, 3637 to histones, 4041, 41f to side chains, 33, 3640, 38ff Potassium channels, voltage-gated, 475t chain topology, 476f conducting pore, 476477, 479, 480f selectivity filter, 476477, 478479 subunit assembly, 476477 voltage sensor, 478479, 479f Potassium currents, 466468, Crpyto, 468t, 468470, 469f; see also HodgkinHuxley equations Potential energy, of a macromolecule, 7983 Poxvirus family, 445t, 446t, 447 pRb, see Retinoblastoma protein Prebötzinger complex, 504 Predictive learning, 533 Prefrontal cortex, 531f, 533 Preinitiation complex, 385, 386387, 386t, 387f, 548 Pre-messenger RNA, 548 Premotor cortex, 512f, 513, 513f Pre-mRNAs, 399403, 401f, 402f Prenyl anchor, 34, 34t, 35f Presenilins, 309310, 310f and Alzheimers disease, 99 Presynaptic terminal, see Active zone Prickle, 317 Primary splice sites, 400401, 401f, 548 Primary structure, 548; see also Protein structure Principle of detailed balance, 217, 218219 Prions, 100, 100t Progestins, 393t Programmed cell death, see Apoptosis Prokaryotes, 13, 910 Prolactin, 286, 287t Prolactin-inhibiting hormone, 287t Proline-recognition modules, 256, 257t Promoter, 118 bacterial, 413f, 414, 414t; see also Control point eukaryotic, 386387, 387f, Cryptp Pro-opiomelanocortin, 286 Prostanoid GPCR, 277t, 294f Prostanoids, 293t, 294 Proteases, 7 Protein backbone, 549; see also Protein structure, Primary structure Protein Data Bank, 5253 Protein dynamics, 7986, 104105 Protein Explorer, 43 Protein folding, 90, 9498, 96t, 97f, 98f, 549; see also Misfolded proteins and diseases, Molecular chaperones Protein interfaces, 7778, 77t Protein kinase A, 120t, 173174, 174t, 180182, 181f, 519t catalysis, 182183, 183f in Aplysia facilitation, 522, 522f in hippocampal LTP, 525526, 525f, 526f in the Hh pathway, 318320, 319ff in yeast general stress response, 130, 130f Index 569 67.
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